Transcription Factor
| Accessions: | UP00236A (UniPROBE 20160601) |
| Names: | Homeodomain protein IRXA2, Iroquois homeobox protein 2, Iroquois related homeobox 2 (Drosophila), Iroquois-class homeodomain protein IRX-2, Irx2, IRX6, MGC103290 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P81066 |
| Description: | Iroquois related homeobox 2 (Drosophila) |
| Length: | 96 |
| Pfam Domains: | 20-76 Homeobox domain 34-73 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 SYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTL 60 61 TQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEG |
| Interface Residues: | 10, 15, 19, 20, 23, 27, 61, 62, 64, 65, 68, 69, 70, 72, 73, 75, 76 |
| 3D-footprint Homologues: | 3a01_E, 1jgg_B, 2r5y_A, 1puf_B, 5jlw_D, 3d1n_M, 4cyc_A, 1ig7_A, 2h1k_B, 2ld5_A, 1e3o_C, 2xsd_C, 7xrc_C, 5hod_A, 3cmy_A, 2hdd_A, 1mnm_C, 1du0_A, 6fqp_B, 4xrm_B, 1nk2_P, 6fqq_E, 4xrs_G, 2d5v_B, 1k61_B, 5zfz_A, 3rkq_B, 1o4x_A, 1fjl_B, 7psx_B, 5flv_I, 1le8_B, 1b72_A, 5zjt_E, 2lkx_A, 1puf_A, 2hos_A |
| Binding Motifs: | UP00236A_1 wwdrTACATGTAarwkw |
| Binding Sites: | AAACATGT AACATGTA AACATGTT ACACGTGT ACATGTAA ACATGTAC ACATGTAG ACATGTAT ACATGTTA ACATGTTC AGTACAAG ATGTACAA ATGTACAT CATACATG CATGTAAC CATGTACA CTTGTACA GCTTGTAC GTACAACA GTACAAGA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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