Transcription Factor

						

			
Accessions: 3kov_A (3D-footprint 20231221), 3kov_B (3D-footprint 20231221), 3kov_I (3D-footprint 20231221), 3kov_J (3D-footprint 20231221), 3p57_A (3D-footprint 20231221), 3p57_B (3D-footprint 20231221), 3p57_C (3D-footprint 20231221), 3p57_D (3D-footprint 20231221), 3p57_I (3D-footprint 20231221), 3p57_J (3D-footprint 20231221)

			
Names: MEF2A_HUMAN, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q02078
Length: 90
Pfam Domains:      9-58 SRF-type transcription factor (DNA-binding and dimerisation domain)
Sequence: 
(in bold interface residues)		   1 GRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTD   60
  61 MDKVLLKYTEYNEPHESRTNSDIVEALNKK
Interface Residues: 2, 3, 14, 17, 18, 22, 56, 67
3D-footprint Homologues: 1hbx_A, 1n6j_A, 1c7u_A, 7x1n_C, 1mnm_A, 7yq3_E
Binding Motifs: 3kov_AB TTAnnnnnAG
3kov_IJ TTnnnnnTAG
3p57_AB TAnnnnTAG
3p57_CD CTannnntAA
3p57_IJ CTAnnnnTAA
Binding Sites: 3kov_C / 3kov_K
3kov_D / 3kov_L
3p57_E / 3p57_G / 3p57_K
3p57_F / 3p57_H / 3p57_L
			
Publications: Wu Y, Dey R, Han A, Jayathilaka N, Philips M, Ye J, Chen L. Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment. Journal of molecular biology 397:520-33 (2010). [Pubmed]


He J, Ye J, Cai Y, Riquelme C, Liu J.O, Liu X, Han A, Chen L. Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic acids research 39:4464-74 (2011). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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