DNA Binding Site

Accessions: 3p57_E (3D-footprint 20231221), 3p57_G (3D-footprint 20231221), 3p57_K (3D-footprint 20231221), 6byy_K (3D-footprint 20231221)
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 14
Type: Heterodimer
Binding TFs: 3p57_B / 3p57_D / 3p57_J (SRF-type transcription factor (DNA-binding and dimerisation domain))
6byy_B (SRF-type transcription factor (DNA-binding and dimerisation domain))
Binding Motifs: 3p57_AB TAnnnnTAG
3p57_CD CTannnntAA
3p57_IJ CTAnnnnTAA
6byy_AB TAnnnnTAG
Publications: He J, Ye J, Cai Y, Riquelme C, Liu J.O, Liu X, Han A, Chen L. Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic acids research 39:4464-74 (2011). [Pubmed]

Lei X, Kou Y, Fu Y, Rajashekar N, Shi H, Wu F, Xu J, Luo Y, Chen L. The Cancer Mutation D83V Induces an α-Helix to β-Strand Conformation Switch in MEF2B. J Mol Biol 430:1157-1172 (2018). [Pubmed]

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