Transcription Factor

Accessions: 6byy_A (3D-footprint 20231221), 6byy_B (3D-footprint 20231221), 6byy_C (3D-footprint 20231221), 6wc2_A (3D-footprint 20231221), 6wc2_I (3D-footprint 20231221)
Names: MEF2 CHIMERA, MEF2A_HUMAN, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1, MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 91
Pfam Domains: 9-58 SRF-type transcription factor (DNA-binding and dimerisation domain)
Sequence:
(in bold interface residues)
1 GRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTD 60
61 MDKVLLKYTEYSEPHESRTNTDILETLKRRE
Interface Residues: 2, 3, 14, 17, 18, 22, 56, 67
3D-footprint Homologues: 1n6j_A, 1c7u_A, 7x1n_C, 1hbx_A, 1mnm_A, 7yq3_E
Binding Motifs: 6byy_AB TAnnnnTAG
6byy_CD TTnnnnnkAs
6wc2_ABO CTAnnnnnGGAAAAngC
6wc2_IJN CTAnnnnnnGAAAAnGC
Binding Sites: 6byy_K
6byy_L
Publications: Lei X, Kou Y, Fu Y, Rajashekar N, Shi H, Wu F, Xu J, Luo Y, Chen L. The Cancer Mutation D83V Induces an α-Helix to β-Strand Conformation Switch in MEF2B. J Mol Biol 430:1157-1172 (2018). [Pubmed]

Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]
Related annotations: PaperBLAST

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