Transcription Factor
| Accessions: | UP00484A (UniPROBE 20160601) |
| Names: | CBF1, CSL, IGKJRB, IGKJRB1, KBF2, MGC61669, RBP-J, RBPJ, RBPJK, RBPSUH, recombination signal binding protein for immunoglobulin kappa J region, SUH |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | recombination signal binding protein for immunoglobulin kappa J region: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcriptio |
| Length: | 427 |
| Pfam Domains: | 24-155 LAG1, DNA binding 156-305 Beta-trefoil DNA-binding domain 333-421 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 ERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKK 60 61 KEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSV 120 121 KMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYL 180 181 HVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLI 240 241 IRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIN 300 301 DGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLR 360 361 VWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFT 420 421 YTPEPGP |
| Interface Residues: | 37, 40, 42, 142, 143, 146, 171, 172, 173 |
| 3D-footprint Homologues: | 5e24_E, 3brd_A, 3iag_C |
| Binding Motifs: | UP00484A_1 tkwksmsCGTGGGAAccastsb UP00484A_4 wtmccrTGGGAAcwwk UP00484A_5 ksmscgTGGGAayswst UP00484A_6 yckwwhscrTGGGAAmywkwkrg UP00484A_7 yykrcaycgTGGGAACcvcdwtg UP00484A_8 tmkrmaycvTGGGAAccmbdwkg UP00484A_9 cwckwwwsCrTGGGAAmhwktkd UP00484A_10 yyckwwhsCgTGGGAAmywytkd UP00484A_11 tykrmwhcvTGGGAAccmswadg UP00484A_2 gvmsCGTGGGAAmywck UP00484A_3 yswrcmgCGTGGGAAccwstsk |
| Binding Sites: | CGTGTGAA GCGTGGGA AATTCCCA AGTGGGAA AGTTCCCA ATGGGAAA ATGGGAAC ATTCCCAC CATGGGAA CCGTGGGA CCTGGGAA CGTGAGAA CGTGGGAA CGTGGGAG CGTTCCCA CTGGGAAA CTGGGAAC CTTCCCAC CTTTCCCA GATTCCCA GCTCCCAC GGTGGGAA GGTTCCCA GTGGGAAA GTGGGAAC GTTTCCCA TATGGGAA TCCCACGA TGGGAAAA TGGGAACA TGTGGGAA |
| Publications: | Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One : (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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