Transcription Factor
| Accessions: | UP00587C (UniPROBE 20160601) |
| Names: | AT591, CMT1D, CMT4E, DKFZp686J1957, E3 SUMO-protein ligase EGR2, Early growth response protein 2, EGR-2, EGR2_E412K, FLJ14547, KROX20, Zinc finger protein Krox-20 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | E3 SUMO-protein ligase EGR2: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. |
| Length: | 110 |
| Pfam Domains: | 15-39 C2H2-type zinc finger 15-39 Zinc finger, C2H2 type 32-55 Zinc-finger double domain 45-67 C2H2-type zinc finger 45-67 Zinc finger, C2H2 type 59-83 Zinc-finger double domain 73-95 Zinc finger, C2H2 type 73-91 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 YPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHL 60 61 TTHIRTHTGEKPFACDYCGRKFARSDKRKRHTKIHLRQKERKSSAPSASV |
| Interface Residues: | 4, 27, 28, 29, 30, 31, 33, 34, 53, 55, 56, 57, 58, 59, 61, 62, 63, 83, 84, 85, 86, 87, 88, 89, 90, 91, 94 |
| 3D-footprint Homologues: | 5ei9_F, 7n5w_A, 6jnm_A, 2kmk_A, 1tf3_A, 6ml4_A, 2gli_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 5kl3_A, 2wbs_A, 1ubd_C, 7ysf_A, 2jpa_A, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 1f2i_J, 8ssu_A, 5v3j_F, 8h9h_G, 7eyi_G, 2lt7_A, 6e94_A, 6wmi_A, 6a57_A, 2drp_D, 3uk3_C, 8cuc_F, 7y3l_A, 5yel_A, 1llm_D, 7txc_E, 5k5i_A, 4m9v_C, 7y3m_I, 8gn3_A, 5yj3_D |
| Binding Motifs: | UP00587C_1 skrgcwrGGGGGGGsrGdyarkk |
| Binding Sites: | ACCCCCCC AGGGGGGG CACCCCCC CCACCCCC CCCACCCC CCCCCCCA CCCCCCCC CCCCCCCG CCCCCCTC CGCCCACC CGCCCCCC CTCCCCCC GCCCACCC GCCCCCCC GGGGGGGA GGGTGGGA ACCCACCC AGGGTGGG CCCACCCA CCCCCCTA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.