DNA Binding Motif
| Accessions: | UP00587C_1 (UniPROBE 20160601) |
| Names: | AT591, CMT1D, CMT4E, DKFZp686J1957, E3 SUMO-protein ligase EGR2, Early growth response protein 2, EGR-2, EGR2_E412K_R1, FLJ14547, KROX20, Zinc finger protein Krox-20 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Length: | 23 |
| Consensus: | skrgcwrGGGGGGGsrGdyarkk |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 0.21 0.34 0.29 0.16 s 02 0.06 0.15 0.38 0.41 k 03 0.32 0.08 0.37 0.23 r 04 0.16 0.15 0.58 0.12 g 05 0.24 0.47 0.16 0.13 c 06 0.27 0.07 0.21 0.45 w 07 0.39 0.03 0.38 0.20 r 08 0.04 0 0.94 0.02 G 09 0.02 0 0.98 0.01 G 10 0 0 0.99 0.01 G 11 0 0.01 0.79 0.20 G 12 0.01 0.02 0.92 0.05 G 13 0.01 0.02 0.96 0.01 G 14 0.01 0.01 0.95 0.02 G 15 0.11 0.37 0.45 0.07 s 16 0.52 0.03 0.41 0.04 r 17 0.10 0.09 0.72 0.09 G 18 0.26 0.10 0.36 0.27 d 19 0.15 0.28 0.22 0.35 y 20 0.62 0.13 0.14 0.11 a 21 0.25 0.19 0.40 0.15 r 22 0.12 0.19 0.44 0.25 k 23 0.14 0.19 0.26 0.42 k |
| Binding TFs: | UP00587C (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger) |
| Binding Sites: | ACCCCCCC AGGGGGGG CACCCCCC CCACCCCC CCCACCCC CCCCCCCA CCCCCCCC CCCCCCCG CCCCCCTC CGCCCACC CGCCCCCC CTCCCCCC GCCCACCC GCCCCCCC GGGGGGGA GGGTGGGA ACCCACCC AGGGTGGG CCCACCCA CCCCCCTA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
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