DNA Binding Site

Accessions: 5x07_D (3D-footprint 20231221), 6ako_B (3D-footprint 20231221), 7cby_A (3D-footprint 20231221)
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 16
Sequence: TCTTGTTTACATTTTG
Type: Heterodimer
Binding TFs: 5x07_F (Fork head domain)
6ako_C (Fork head domain)
7cby_C (Fork head domain)
Binding Motifs: 5x07_F TAAACA
6ako_C TgtTTA
7cby_C TAAACA
Publications: Li J, Dantas Machado AC, Guo M, Sagendorf JM, Zhou Z, Jiang L, Chen X, Wu D, Qu L, Chen Z, Chen L, Rohs R, Chen Y. Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site. Biochemistry 56:3745-3753 (2017). [Pubmed]

Chen X, Wei H, Li J, Liang X, Dai S, Jiang L, Guo M, Qu L, Chen Z, Chen L, Chen Y. Structural basis for DNA recognition by FOXC2. Nucleic Acids Res 47:3752-3764 (2019). [Pubmed]

Dai S, Li J, Zhang H, Chen X, Guo M, Chen Z, Chen Y. Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations. J Mol Biol 432:6146-6156 (2020). [Pubmed]

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