DNA Binding Site

						

			
Accessions: 2a07_B (3D-footprint 20231221), 2a07_D (3D-footprint 20231221), 2as5_A (3D-footprint 20231221), 2as5_C (3D-footprint 20231221), 3qrf_C (3D-footprint 20231221), 4wk8_A (3D-footprint 20231221)

			
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 19
Sequence: AGGAAAATTTGTTTCATAG
Type: Heterodimer
Binding TFs: 2a07_J / 2a07_K (Fork head domain)
2as5_M / 2as5_N (Rel homology domain (RHD), IPT/TIG domain)
4wk8_G (Fork head domain)
3qrf_G (Fork head domain)
Binding Motifs: 2a07_FJ ACAAA
2a07_IK tTTGTT
2a07_J TTTg
2as5_FN GGArnannTGnTT
2as5_GM aAnCannnnnTCC
2as5_N TTtTCCT
3qrf_G GAAACA
4wk8_FG ATTTG
			
Publications: Stroud J.C, Wu Y, Bates D.L, Han A, Nowick K, Paabo S, Tong H, Chen L. Structure of the forkhead domain of FOXP2 bound to DNA. Structure (London, England : 1993) 14:159-66 (2006). [Pubmed]


Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A.D, Stroud J.C, Bates D.L, Guo L, Han A, Ziegler S.F, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126:375-87 (2006). [Pubmed]


Bandukwala H.S, Wu Y, Feuerer M, Chen Y, Barboza B, Ghosh S, Stroud J.C, Benoist C, Mathis D, Rao A, Chen L. Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity 34:479-91 (2011). [Pubmed]


Chen Y, Chen C, Zhang Z, Liu C.C, Johnson M.E, Espinoza C.A, Edsall L.E, Ren B, Zhou X.J, Grant S.F, Wells A.D, Chen L. DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic acids research 43:1268-82 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.