Transcription Factor

						

			
Accessions: 2a07_J (3D-footprint 20231221), 2a07_K (3D-footprint 20231221), 2as5_F (3D-footprint 20231221), 2as5_G (3D-footprint 20231221)

			
Names: CAG repeat protein 44, Forkhead box protein P2, FOXP2_HUMAN, Trinucleotide repeat-containing gene 10 protein
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: O15409
Length: 83
Pfam Domains:      3-80 Fork head domain
Sequence: 
(in bold interface residues)		   1 IVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKC   60
  61 FVRVENVKGAVWTVDEVEYQKRR
Interface Residues: 43, 46, 48, 49, 50, 52, 53, 54, 56, 57, 68
3D-footprint Homologues: 3l2c_A, 7vox_H, 2hdc_A, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 3qrf_G
Binding Motifs: 2a07_FJ ACAAA
2a07_IK tTTGTT
2a07_J TTTg
2as5_FN GGArnannTGnTT
2as5_GM aAnCannnnnTCC
Binding Sites: 2a07_A / 2a07_C
2a07_B / 2a07_D
			
Publications: Stroud J.C, Wu Y, Bates D.L, Han A, Nowick K, Paabo S, Tong H, Chen L. Structure of the forkhead domain of FOXP2 bound to DNA. Structure (London, England : 1993) 14:159-66 (2006). [Pubmed]


Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A.D, Stroud J.C, Bates D.L, Guo L, Han A, Ziegler S.F, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126:375-87 (2006). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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