Transcription Factor
Accessions: | 2as5_M (3D-footprint 20231221), 2as5_N (3D-footprint 20231221) |
Names: | NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | Q13469 |
Length: | 287 |
Pfam Domains: | 19-179 Rel homology domain (RHD) 198-284 IPT/TIG domain |
Sequence: (in bold interface residues) | 1 ASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMEN 60 61 KPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRA 120 121 TIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQ 180 181 RSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKD 240 241 KSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV |
Interface Residues: | 30, 32, 33, 35, 36, 39, 129, 146, 179, 180, 181, 210, 211, 243, 273, 274 |
3D-footprint Homologues: | 1p7h_L, 1a66_A, 1imh_C, 2o61_A, 1nfk_A |
Binding Motifs: | 2as5_FN GGArnannTGnTT 2as5_GM aAnCannnnnTCC 2as5_N TTtTCCT |
Binding Sites: | 2as5_B / 2as5_D 2as5_A / 2as5_C |
Publications: | Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A.D, Stroud J.C, Bates D.L, Guo L, Han A, Ziegler S.F, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126:375-87 (2006). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.