Transcription Factor

Accessions: 2as5_M (3D-footprint 20231221), 2as5_N (3D-footprint 20231221)
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 287
Pfam Domains: 19-179 Rel homology domain (RHD)
198-284 IPT/TIG domain
Sequence:
(in bold interface residues)
1 ASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMEN 60
61 KPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRA 120
121 TIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQ 180
181 RSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKD 240
241 KSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 30, 32, 33, 35, 36, 39, 129, 146, 179, 180, 181, 210, 211, 243, 273, 274
3D-footprint Homologues: 1p7h_L, 1a66_A, 1imh_C, 2o61_A, 1nfk_A
Binding Motifs: 2as5_FN GGArnannTGnTT
2as5_GM aAnCannnnnTCC
2as5_N TTtTCCT
Binding Sites: 2as5_B / 2as5_D
2as5_A / 2as5_C
Publications: Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A.D, Stroud J.C, Bates D.L, Guo L, Han A, Ziegler S.F, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126:375-87 (2006). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.