Transcription Factor

						

			
Accessions: 2as5_M (3D-footprint 20231221), 2as5_N (3D-footprint 20231221)

			
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 287
Pfam Domains:    19-179 Rel homology domain (RHD)
  198-284 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 ASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMEN   60
  61 KPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRA  120
 121 TIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQ  180
 181 RSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKD  240
 241 KSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 30, 32, 33, 35, 36, 39, 129, 146, 179, 180, 181, 210, 211, 243, 273, 274
3D-footprint Homologues: 1imh_C, 1p7h_L, 1a66_A, 2o61_A, 1nfk_A
Binding Motifs: 2as5_FN GGArnannTGnTT
2as5_GM aAnCannnnnTCC
2as5_N TTtTCCT
Binding Sites: 2as5_B / 2as5_D
2as5_A / 2as5_C
			
Publications: Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A.D, Stroud J.C, Bates D.L, Guo L, Han A, Ziegler S.F, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126:375-87 (2006). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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