DNA Binding Site

Accessions: MA0764.2.20 (JASPAR 2024), 3zp5_G (3D-footprint 20231221), 4bnc_B (3D-footprint 20231221), 4uuv_W (3D-footprint 20231221), 5e8i_E (3D-footprint 20231221)
Organisms: Homo sapiens
Libraries: JASPAR 2024 1, 3D-footprint 20231221 2
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
2 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 10
Sequence: ACCGGAAGTG
Type: Heterodimer
Binding TFs: P43268 (Ets-domain, PEA3 subfamily ETS-domain transcription factor N terminal domain)
4uuv_S (Ets-domain)
4uuv_V (Ets-domain)
3zp5_A (Ets-domain)
4bnc_A (Ets-domain)
5e8i_D (Ets-domain)
P43268
Binding Motifs: MA0764.2 rcAGGAAGyr
3zp5_A tCCG
4bnc_A cTTCCG
4uuv_S ctTCCG
4uuv_SV CGGAAnTnnnCGGAnG
5e8i_D CGGAAG
Publications: Cooper C.D, Newman J.A, Aitkenhead H, Allerston C.K, Gileadi O. Structures of the Ets Domains of Transcription Factors ETV1, ETV4, ETV5 and FEV: Determinants of DNA Binding and Redox Regulation by Disulfide bond formation. The Journal of biological chemistry : (2015). [Pubmed]

Hou C, Tsodikov OV. Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1. Biochemistry 54:7365-74 (2015). [Pubmed]

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.