Transcription Factor

						

			
Accessions: 5e8i_D (3D-footprint 20231221), 5jvt_D (3D-footprint 20231221)

			
Names: FLI1_HUMAN, Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q01543
Length: 93
Pfam Domains:      2-84 Ets-domain
Sequence: 
(in bold interface residues)		   1 GQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRA   60
  61 LRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQP
Interface Residues: 55, 56, 58, 59, 60, 62, 63, 77
3D-footprint Homologues: 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C
Binding Motifs: 5e8i_D CGGAAG
5jvt_AD TTCCGnnGgnnCGGAa
Binding Sites: 5e8i_E
5e8i_F
5jvt_B / 5jvt_E
5jvt_C / 5jvt_F
			
Publications: Hou C, Tsodikov OV. Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1. Biochemistry 54:7365-74 (2015). [Pubmed]


Hou C, Weidenbach S, Cano KE, Wang Z, Mitra P, Ivanov DN, Rohr J, Tsodikov OV. Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res 44:8990-9004 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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