Transcription Factor

Accessions: CcpA (DBTBS 1.0), 1rzr_A (3D-footprint 20231221), 1rzr_C (3D-footprint 20231221), 1rzr_D (3D-footprint 20231221), 1rzr_G (3D-footprint 20231221)
Names: Catabolite control protein A, CcpA, CCPA_BACME, Glucose-resistance amylase regulator
Organisms: Bacillus subtilis, Bacillus megaterium
Libraries: DBTBS 1.0 1, 3D-footprint 20231221 2
1 Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic acids research 36:D93-6 (2008). [Pubmed]
2 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P46828
Length: 332
Pfam Domains: 4-49 Bacterial regulatory proteins, lacI family
61-322 Periplasmic binding proteins and sugar binding domain of LacI family
63-312 Periplasmic binding protein domain
169-331 Periplasmic binding protein-like domain
Sequence:
(in bold interface residues)
1 MNVTIYDVAREASVSMATVSRVVNGNPNVKPSTRKKVLETIERLGYRPNAVARGLASKKT 60
61 TTVGVIIPDISNIFYAELARGIEDIATMYKYNIILSNSDQNQDKELHLLNNMLGKQVDGI 120
121 IFMSGNVTEEHVEELKKSPVPVVLAASIESTNQIPSVTIDYEQAAFDAVQSLIDSGHKNI 180
181 AFVSGTLEEPINHAKKVKGYKRALTESGLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKP 240
241 TAIFVGTDEMALGVIHGAQDRGLNVPNDLEIIGFDNTRLSTMVRPQLTSVVQPMYDIGAV 300
301 AMRLLTKYMNKETVDSSIVQLPHRIEFRQSTK
Interface Residues: 5, 6, 15, 16, 17, 18, 20, 21, 27, 28, 29, 52, 55, 56
3D-footprint Homologues: 1efa_B, 3oqm_C, 7ce1_D, 1l1m_B, 1zvv_A, 1jft_A
Binding Motifs: CcpA TGwAARCGbTwtC
1rzr_AD TGTnAGCGCTnTCA
1rzr_C CGCTnACA
1rzr_CG TGTnAGCGCTTTCA
Binding Sites: ackA_1
ackA_2
acoA_2
acoR
acsA_1
acuA_1
amyE_1
araA_3
araB
araE_3
bglP_1
bglS_1
ccpC_1
citM_1
citZ_1
cydA_1
dctP_1
dra_1
galT
glpF_1
gntR_1
hutP_2
hutP_3
ilvB_1
iolB
kdgA
lcfA
levD_1
licB_1
malA_1
mmgA_1
mmsA_1
msmX
phoP_1
pta_1
pta_2
rbsR_3
sigL
treP_1
uxaC_1
xylA_1
xynP_1
ydhO
yobO
yxjC_1
yxkJ
1rzr_B / 1rzr_R
1rzr_E / 1rzr_H
Publications: Schumacher M.A, Allen G.S, Diel M, Seidel G, Hillen W, Brennan R.G. Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. Cell 118:731-41 (2004). [Pubmed]
Related annotations: PaperBLAST

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