DNA Binding Motif
| Accessions: | CcpA (DBTBS 1.0) |
| Names: | CcpA |
| Organisms: | Bacillus subtilis |
| Libraries: | DBTBS 1.0 1 1 Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic acids research 36:D93-6 (2008). [Pubmed] |
| Length: | 13 |
| Consensus: | TGwAARCGbTwtC |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 0.01 0 0 0.99 T 02 0 0 1 0 G 03 0.52 0 0.11 0.37 w 04 0.92 0 0 0.08 A 05 0.89 0 0 0.11 A 06 0.26 0 0.74 0 R 07 0.03 0.97 0 0 C 08 0.01 0 0.93 0.06 G 09 0 0.41 0.31 0.28 b 10 0.19 0 0 0.81 T 11 0.31 0 0.15 0.54 w 12 0.24 0.15 0 0.60 t 13 0.22 0.75 0 0.03 C |
| Binding TFs: | CcpA (Bacterial regulatory proteins, lacI family, Periplasmic binding proteins and sugar binding domain of LacI family, Periplasmic binding protein-like domain, Periplasmic binding protein domain) |
| Binding Sites: | ackA_1 ackA_2 acoA_2 acoR acsA_1 acuA_1 amyE_1 araA_3 araB araE_3 bglP_1 bglS_1 ccpC_1 citM_1 citZ_1 cydA_1 dctP_1 dra_1 galT glpF_1 gntR_1 hutP_2 hutP_3 ilvB_1 iolB kdgA lcfA levD_1 licB_1 malA_1 mmgA_1 mmsA_1 msmX phoP_1 pta_1 pta_2 rbsR_3 sigL treP_1 uxaC_1 xylA_1 xynP_1 ydhO yobO yxjC_1 yxkJ |
| Publications: | Grundy F.J, Waters D.A, Allen S.H, Henkin T.M. Regulation of the Bacillus subtilis acetate kinase gene by CcpA. Journal of bacteriology 175:7348-55 (1993). [Pubmed] Miwa Y, Nakata A, Ogiwara A, Yamamoto M, Fujita Y. Evaluation and characterization of catabolite-responsive elements (cre) of Bacillus subtilis. Nucleic acids research 28:1206-10 (2000). [Pubmed] Ali N.O, Bignon J, Rapoport G, Debarbouille M. Regulation of the acetoin catabolic pathway is controlled by sigma L in Bacillus subtilis. Journal of bacteriology 183:2497-504 (2001). [Pubmed] Grundy F.J, Turinsky A.J, Henkin T.M. Catabolite regulation of Bacillus subtilis acetate and acetoin utilization genes by CcpA. Journal of bacteriology 176:4527-33 (1994). [Pubmed] Kim J.H, Guvener Z.T, Cho J.Y, Chung K.C, Chambliss G.H. Specificity of DNA binding activity of the Bacillus subtilis catabolite control protein CcpA. Journal of bacteriology 177:5129-34 (1995). [Pubmed] Kim J.H, Yang Y.K, Chambliss G.H. Evidence that Bacillus catabolite control protein CcpA interacts with RNA polymerase to inhibit transcription. Molecular microbiology 56:155-62 (2005). [Pubmed] Inácio J.M, Costa C, de Sá-Nogueira I. Distinct molecular mechanisms involved in carbon catabolite repression of the arabinose regulon in Bacillus subtilis. Microbiology (Reading, England) 149:2345-55 (2003). [Pubmed] Krüger S, Gertz S, Hecker M. Transcriptional analysis of bglPH expression in Bacillus subtilis: evidence for two distinct pathways mediating carbon catabolite repression. Journal of bacteriology 178:2637-44 (1996). [Pubmed] Krüger S, Stülke J, Hecker M. Catabolite repression of beta-glucanase synthesis in Bacillus subtilis. Journal of general microbiology 139:2047-54 (1993). [Pubmed] Kim H.J, Jourlin-Castelli C, Kim S.I, Sonenshein A.L. Regulation of the bacillus subtilis ccpC gene by ccpA and ccpC. Molecular microbiology 43:399-410 (2002). [Pubmed] Kim H.J, Roux A, Sonenshein A.L. Direct and indirect roles of CcpA in regulation of Bacillus subtilis Krebs cycle genes. Molecular microbiology 45:179-90 (2002). [Pubmed] Puri-Taneja A, Schau M, Chen Y, Hulett F.M. Regulators of the Bacillus subtilis cydABCD operon: identification of a negative regulator, CcpA, and a positive regulator, ResD. Journal of bacteriology 189:3348-58 (2007). [Pubmed] Asai K, Baik S.H, Kasahara Y, Moriya S, Ogasawara N. Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis. Microbiology (Reading, England) 146 ( Pt 2):263-71 (2000). [Pubmed] Darbon E, Servant P, Poncet S, Deutscher J. Antitermination by GlpP, catabolite repression via CcpA and inducer exclusion triggered by P-GlpK dephosphorylation control Bacillus subtilis glpFK expression. Molecular microbiology 43:1039-52 (2002). [Pubmed] Miwa Y, Fujita Y. Promoter-independent catabolite repression of the Bacillus subtilis gnt operon. Journal of biochemistry 113:665-71 (1993). [Pubmed] Chauvaux S, Paulsen I.T, Saier M.H. CcpB, a novel transcription factor implicated in catabolite repression in Bacillus subtilis. Journal of bacteriology 180:491-7 (1998). [Pubmed] Wray L.V, Pettengill F.K, Fisher S.H. Catabolite repression of the Bacillus subtilis hut operon requires a cis-acting site located downstream of the transcription initiation site. Journal of bacteriology 176:1894-902 (1994). [Pubmed] Tojo S, Satomura T, Morisaki K, Deutscher J, Hirooka K, Fujita Y. Elaborate transcription regulation of the Bacillus subtilis ilv-leu operon involved in the biosynthesis of branched-chain amino acids through global regulators of CcpA, CodY and TnrA. Molecular microbiology 56:1560-73 (2005). [Pubmed] Shivers R.P, Sonenshein A.L. Bacillus subtilis ilvB operon: an intersection of global regulons. Molecular microbiology 56:1549-59 (2005). [Pubmed] Martin-Verstraete I, Stülke J, Klier A, Rapoport G. Two different mechanisms mediate catabolite repression of the Bacillus subtilis levanase operon. Journal of bacteriology 177:6919-27 (1995). [Pubmed] Tobisch S, Zühlke D, Bernhardt J, Stülke J, Hecker M. Role of CcpA in regulation of the central pathways of carbon catabolism in Bacillus subtilis. Journal of bacteriology 181:6996-7004 (1999). [Pubmed] Tobisch S, Glaser P, Krüger S, Hecker M. Identification and characterization of a new beta-glucoside utilization system in Bacillus subtilis. Journal of bacteriology 179:496-506 (1997). [Pubmed] Yamamoto H, Serizawa M, Thompson J, Sekiguchi J. Regulation of the glv operon in Bacillus subtilis: YfiA (GlvR) is a positive regulator of the operon that is repressed through CcpA and cre. Journal of bacteriology 183:5110-21 (2001). [Pubmed] Bryan E.M, Beall B.W, Moran C.P. A sigma E dependent operon subject to catabolite repression during sporulation in Bacillus subtilis. Journal of bacteriology 178:4778-86 (1996). [Pubmed] Puri-Taneja A, Paul S, Chen Y, Hulett F.M. CcpA causes repression of the phoPR promoter through a novel transcription start site, P(A6). Journal of bacteriology 188:1266-78 (2006). [Pubmed] Presecan-Siedel E, Galinier A, Longin R, Deutscher J, Danchin A, Glaser P, Martin-Verstraete I. Catabolite regulation of the pta gene as part of carbon flow pathways in Bacillus subtilis. Journal of bacteriology 181:6889-97 (1999). [Pubmed] Woodson K, Devine K.M. Analysis of a ribose transport operon from Bacillus subtilis. Microbiology (Reading, England) 140 ( Pt 8):1829-38 (1994). [Pubmed] Choi S.K, Saier M.H. Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis: potential connection between carbon and nitrogen metabolism. Journal of bacteriology 187:6856-61 (2005). [Pubmed] Gärtner D, Geissendörfer M, Hillen W. Expression of the Bacillus subtilis xyl operon is repressed at the level of transcription and is induced by xylose. Journal of bacteriology 170:3102-9 (1988). [Pubmed] Jacob S, Allmansberger R, Gärtner D, Hillen W. Catabolite repression of the operon for xylose utilization from Bacillus subtilis W23 is mediated at the level of transcription and depends on a cis site in the xylA reading frame. Molecular & general genetics : MGG 229:189-96 (1991). [Pubmed] Kraus A, Hueck C, Gärtner D, Hillen W. Catabolite repression of the Bacillus subtilis xyl operon involves a cis element functional in the context of an unrelated sequence, and glucose exerts additional xylR-dependent repression. Journal of bacteriology 176:1738-45 (1994). [Pubmed] Lindner C, Stülke J, Hecker M. Regulation of xylanolytic enzymes in Bacillus subtilis. Microbiology (Reading, England) 140 ( Pt 4):753-7 (1994). [Pubmed] Galinier A, Deutscher J, Martin-Verstraete I. Phosphorylation of either crh or HPr mediates binding of CcpA to the bacillus subtilis xyn cre and catabolite repression of the xyn operon. Journal of molecular biology 286:307-14 (1999). [Pubmed] |
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