Transcription Factor

						

			
Accessions: UP00629B (UniPROBE 20160601)

			
Names: zinc finger protein 200, ZNF200_H322Y, ZNFMF
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: zinc finger protein 200: Could have a role in spermatogenesis.
Length: 158
Pfam Domains:     15-35 Zinc-finger of C2H2 type
    15-37 C2H2-type zinc finger
    15-37 Zinc finger, C2H2 type
    15-37 C2H2-type zinc finger
    32-54 Zinc-finger double domain
    43-65 C2H2-type zinc finger
    43-61 C2H2-type zinc finger
    43-65 Zinc finger, C2H2 type
    57-81 Zinc-finger double domain
    71-90 C2H2-type zinc finger
    71-83 C2H2-type zinc finger
    71-90 Zinc finger, C2H2 type
   87-108 Zinc-finger double domain
   98-121 C2H2-type zinc finger
   99-121 Zinc finger, C2H2 type
   99-121 C2H2-type zinc finger
  116-137 Zinc-finger double domain
  127-141 C2H2-type zinc finger
  127-149 Zinc finger, C2H2 type
  129-149 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 SIIALTRNRRTRRWYTCPLCGKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNK   60
  61 HERIHTGEKPYSCSQCGKNFRQNSYRSRHEGIHIREKIFKCPECGKTFPKNEEFVLHLQS  120
 121 HEAERPYGCKKCGRRFGRLSNCTRHEKTHSACKTRKQK
Interface Residues: 1, 2, 5, 7, 11, 15, 25, 26, 27, 28, 29, 31, 32, 34, 35, 38, 53, 54, 55, 56, 57, 59, 60, 61, 81, 82, 83, 84, 85, 86, 87, 88, 89, 92, 109, 110, 111, 112, 113, 115, 116, 138, 139, 140, 141, 144
3D-footprint Homologues: 5v3j_F, 8ssu_A, 2kmk_A, 6jnm_A, 8cuc_F, 7y3l_A, 7n5w_A, 3uk3_C, 1tf3_A, 1tf6_A, 7w1m_H, 4x9j_A, 6blw_A, 5kkq_D, 1ubd_C, 5ei9_F, 1mey_C, 5kl3_A, 2drp_D, 1f2i_J, 6u9q_A, 5und_A, 2gli_A, 1g2f_F, 7eyi_G, 8h9h_G, 2i13_A, 7y3m_I, 6e94_A, 6wmi_A, 6a57_A, 2jpa_A, 8ssq_A, 1llm_D, 2wbs_A, 6ml4_A, 5yel_A, 8gn3_A, 5yj3_D, 5k5i_A, 7txc_E, 4m9v_C, 2lt7_A, 7ysf_A, 6dta_B, 5k5l_F
Binding Motifs: UP00629B_1 dttdryggGGtGgGwawakamck
Binding Sites: ACCCCGCC
AGGGGCGG
CCCACCCC
CCCGCCCA
GCCCACCC
GGCGGGGA
AAAAAAAA
AAAAATGA
AAAATGAG
AAATGAGT
AATGAGTA
ACCCACCC
ATTGAGTA
ATTGTTAC
ATTTGAGA
CCCACCCA
CCTCCCCA
GGTGGGGA
GTGAGCAA
TATCTCAA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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