Transcription Factor
| Accessions: | 1lb2_A (3D-footprint 20231221), 3iyd_H (3D-footprint 20231221) |
| Names: | cAMP receptor protein, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP, CAP, Catabolite activator protein, CATABOLITE GENE ACTIVATOR PROTEIN, CRP_ECOLI, Catabolite gene activator |
| Organisms: | Escherichia coli, strain K12 |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P0ACJ8 |
| Length: | 201 |
| Pfam Domains: | 14-102 Cyclic nucleotide-binding domain 133-197 Crp-like helix-turn-helix domain 157-188 Bacterial regulatory proteins, crp family |
| Sequence: (in bold interface residues) | 1 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGD 60 61 FIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTS 120 121 EKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILK 180 181 MLEDQNLISAHGKTIVVYGTR |
| Interface Residues: | 18, 72, 157, 162, 171, 172, 173, 174, 176, 177 |
| 3D-footprint Homologues: | 3iyd_H, 4a12_B, 2xro_E, 3q5f_A, 7pza_B, 3e6c_C, 4i2o_B, 3mzh_A, 5i2d_R |
| Binding Motifs: | 1lb2_ABE TwnnnnnnnnnntGtGA 3iyd_H AnnnnTGTGaT |
| Binding Sites: | 1lb2_J 1lb2_K 3iyd_I 3iyd_J |
| Publications: | Benoff B., Yang H., Lawson CL., Parkinson G., Liu J., Blatter E., Ebright YW., Berman HM., Ebright RH. Structural basis of transcription activation: the CAP-alpha CTD-DNA complex. Science. 297(5586):1562-6 (2002). [Pubmed] Hudson B.P, Quispe J, Lara-González S, Kim Y, Berman H.M, Arnold E, Ebright R.H, Lawson C.L. Three-dimensional EM structure of an intact activator-dependent transcription initiation complex. Proceedings of the National Academy of Sciences of the United States of America 106:19830-5 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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