Transcription Factor
Accessions: | 1lb2_A (3D-footprint 20231221), 3iyd_H (3D-footprint 20231221) |
Names: | cAMP receptor protein, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP, CAP, Catabolite activator protein, CATABOLITE GENE ACTIVATOR PROTEIN, CRP_ECOLI, Catabolite gene activator |
Organisms: | Escherichia coli, strain K12 |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P0ACJ8 |
Length: | 201 |
Pfam Domains: | 14-102 Cyclic nucleotide-binding domain 133-197 Crp-like helix-turn-helix domain 157-188 Bacterial regulatory proteins, crp family |
Sequence: (in bold interface residues) | 1 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGD 60 61 FIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTS 120 121 EKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILK 180 181 MLEDQNLISAHGKTIVVYGTR |
Interface Residues: | 18, 72, 157, 162, 171, 172, 173, 174, 176, 177 |
3D-footprint Homologues: | 3iyd_H, 4a12_B, 2xro_E, 3mzh_A, 5i2d_R, 3q5f_A, 7pza_B, 3e6c_C, 4i2o_B |
Binding Motifs: | 1lb2_ABE TwnnnnnnnnnntGtGA 3iyd_H AnnnnTGTGaT |
Binding Sites: | 1lb2_J 1lb2_K 3iyd_I 3iyd_J |
Publications: | Benoff B., Yang H., Lawson CL., Parkinson G., Liu J., Blatter E., Ebright YW., Berman HM., Ebright RH. Structural basis of transcription activation: the CAP-alpha CTD-DNA complex. Science. 297(5586):1562-6 (2002). [Pubmed] Hudson B.P, Quispe J, Lara-González S, Kim Y, Berman H.M, Arnold E, Ebright R.H, Lawson C.L. Three-dimensional EM structure of an intact activator-dependent transcription initiation complex. Proceedings of the National Academy of Sciences of the United States of America 106:19830-5 (2009). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.