Transcription Factor
| Accessions: | UP00404A (UniPROBE 20160601) |
| Names: | 2610036A20Rik, A230104O07Rik, AW111824, BB183398, E74-like factor 2, Elf2, ETS-related transcription factor Elf-2, EU32, MGC102660, Nerf, NERF-1A, NERF-1B, NERF-2, New ETS-related factor |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q9JHC9 |
| Description: | ETS-related transcription factor Elf-2: Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter |
| Length: | 118 |
| Pfam Domains: | 17-99 Ets-domain |
| Sequence: (in bold interface residues) | 1 PELGIKKKAREGKGNTTYLWEFLLDLLQDKNTCPRYIKWTQREKGIFKLVDSKAVSKLWG 60 61 KHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKDMPKNIVVIDDDKSETCPE |
| Interface Residues: | 71, 72, 74, 75, 76, 78, 79, 93 |
| 3D-footprint Homologues: | 1dux_F, 4uno_A, 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 8ee9_F, 3jtg_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4r4e_B |
| Binding Motifs: | UP00404A_1 abshACTTCCGGkwky |
| Binding Sites: | AACCGGAA AACTTCCG ACCCGGAA ACCGGAAG ACTTCCGC ACTTCCTG AGTTCCGG ATCCGGAA ATTTCCGG CACTTCCG CCCGGAAA CCCGGAAG CCGGAAAC CCGGAAGA CCGGAAGC CGGAAGTA CGGAAGTC CTTCCGGA TACCGGAA TTCCGGAA |
| Publications: | Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] |
| Related annotations: | PaperBLAST |
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