Transcription Factor
Accessions: | 1o3q_A (3D-footprint 20231221), 1o3r_A (3D-footprint 20231221), 1zrc_B (3D-footprint 20231221), 1zrd_B (3D-footprint 20231221), 1zre_B (3D-footprint 20231221), 2cgp_A (3D-footprint 20231221) |
Names: | cAMP receptor protein, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP, CAP, Catabolite activator protein, CATABOLITE GENE ACTIVATOR PROTEIN, CRP_ECOLI, Catabolite gene activator |
Organisms: | Escherichia coli, strain K12 |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P0ACJ8 |
Length: | 200 |
Pfam Domains: | 15-103 Cyclic nucleotide-binding domain 134-198 Crp-like helix-turn-helix domain 158-189 Bacterial regulatory proteins, crp family |
Sequence: (in bold interface residues) | 1 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQG 60 61 DFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVT 120 121 SEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRIL 180 181 KMLEDQNLISAHGKTIVVYG |
Interface Residues: | 19, 73, 158, 163, 172, 173, 174, 175, 177, 178 |
3D-footprint Homologues: | 3iyd_H, 4a12_B, 2xro_E, 3mzh_A, 7pza_B, 3e6c_C, 4i2o_B, 5i2d_R |
Binding Motifs: | 1zrd_B TgaGA 1o3q_A TGTGA 1o3r_A AAntGcGA 1zrc_B TGTGA 1zre_B TCcCA 2cgp_A tGTGAc |
Binding Sites: | 1o3q_B 1o3q_C 1o3r_B 1o3r_C 1zrc_Y 1zrc_Z 1zrd_Y 1zrd_Z 1zre_Y 1zre_Z 2cgp_B 2cgp_C |
Publications: | Chen S, Vojtechovsky J, Parkinson G.N, Ebright R.H, Berman H.M. Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: DNA binding specificity based on energetics of DNA kinking. Journal of molecular biology 314:63-74 (2001). [Pubmed] Napoli A.A, Lawson C.L, Ebright R.H, Berman H.M. Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. Journal of molecular biology 357:173-83 (2006). [Pubmed] Passner JM., Steitz TA. The structure of a CAP-DNA complex having two cAMP molecules bound to each monomer. Proc Natl Acad Sci U S A. 94(7):2843-7 (1997). [Pubmed] |
Related annotations: | PaperBLAST |
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