Transcription Factor
Accessions: | 1u8r_A (3D-footprint 20231221), 1u8r_B (3D-footprint 20231221), 1u8r_C (3D-footprint 20231221), 1u8r_D (3D-footprint 20231221), 1u8r_G (3D-footprint 20231221), 1u8r_I (3D-footprint 20231221) |
Names: | IDER_MYCTU, Iron-dependent repressor ideR |
Organisms: | Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P9WMH0 |
Length: | 221 |
Pfam Domains: | 3-62 Iron dependent repressor, N-terminal DNA binding domain 11-68 Winged helix DNA-binding domain 65-134 Iron dependent repressor, metal binding and dimerisation domain 143-220 FeoA domain |
Sequence: (in bold interface residues) | 1 MNELVDTTEMYLRTIYDLEEEGVTPLRARIAERLDQSGPTVSQTVSRMERDGLLRVAGDR 60 61 HLELTEKGRALAIAVMRKHRLAERLLVDVIGLPWEEVHAEACRWEHVMSEDVERRLVKVL 120 121 NNPTTSPFGNPIPGLDELGVGLVRLTELPAGSPVAVVVRQLTEHVQGDIDLITRLKDAGV 180 181 VPNARVTVETTPGGGVTIVIPGHENVTLPHEMAHAVKVEKV |
Interface Residues: | 37, 38, 39, 40, 42, 43, 44, 47, 58 |
3D-footprint Homologues: | 6jbx_A, 2isz_B, 7b24_C, 1ddn_B, 1f5t_A, 4lln_I, 1u8r_B, 4fx4_B |
Binding Motifs: | 1u8r_ABCD AGCAcAGGCTgCCCTAA 1u8r_B CCcTaA 1u8r_GHIJ TTAGCACAGGCTGCCCT |
Binding Sites: | 1u8r_E 1u8r_F |
Publications: | Wisedchaisri G, Holmes R.K, Hol W.G. Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions. Journal of molecular biology 342:1155-69 (2004). [Pubmed] |
Related annotations: | PaperBLAST |
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