Transcription Factor

						

			
Accessions: 1u8r_A (3D-footprint 20231221), 1u8r_B (3D-footprint 20231221), 1u8r_C (3D-footprint 20231221), 1u8r_D (3D-footprint 20231221), 1u8r_G (3D-footprint 20231221), 1u8r_I (3D-footprint 20231221)

			
Names: IDER_MYCTU, Iron-dependent repressor ideR
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P9WMH0
Length: 221
Pfam Domains:      3-62 Iron dependent repressor, N-terminal DNA binding domain
    11-68 Winged helix DNA-binding domain
   65-134 Iron dependent repressor, metal binding and dimerisation domain
  143-220 FeoA domain
Sequence: 
(in bold interface residues)		   1 MNELVDTTEMYLRTIYDLEEEGVTPLRARIAERLDQSGPTVSQTVSRMERDGLLRVAGDR   60
  61 HLELTEKGRALAIAVMRKHRLAERLLVDVIGLPWEEVHAEACRWEHVMSEDVERRLVKVL  120
 121 NNPTTSPFGNPIPGLDELGVGLVRLTELPAGSPVAVVVRQLTEHVQGDIDLITRLKDAGV  180
 181 VPNARVTVETTPGGGVTIVIPGHENVTLPHEMAHAVKVEKV
Interface Residues: 37, 38, 39, 40, 42, 43, 44, 47, 58
3D-footprint Homologues: 7b24_C, 1ddn_B, 1f5t_A, 4lln_I, 1u8r_B, 6jbx_A, 2isz_B, 4fx4_B
Binding Motifs: 1u8r_ABCD AGCAcAGGCTgCCCTAA
1u8r_B CCcTaA
1u8r_GHIJ TTAGCACAGGCTGCCCT
Binding Sites: 1u8r_E
1u8r_F
			
Publications: Wisedchaisri G, Holmes R.K, Hol W.G. Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions. Journal of molecular biology 342:1155-69 (2004). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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