DNA Binding Site

						

			
Accessions: 1u8r_F (3D-footprint 20231221), 1u8r_L (3D-footprint 20231221), 2isz_F (3D-footprint 20231221), 2it0_F (3D-footprint 20231221)

			
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 32
Sequence: CACTAAAATTAGGGCAGCCTGTGCTAACAGGG
Type: Heterodimer
Binding TFs: 1u8r_B / 1u8r_D (Iron dependent repressor, N-terminal DNA binding domain, Iron dependent repressor, metal binding and dimerisation domain, FeoA domain, Winged helix DNA-binding domain)
1u8r_J (Iron dependent repressor, N-terminal DNA binding domain, Iron dependent repressor, metal binding and dimerisation domain, FeoA domain, Winged helix DNA-binding domain)
2isz_B / 2isz_D (Iron dependent repressor, N-terminal DNA binding domain, Iron dependent repressor, metal binding and dimerisation domain, Winged helix DNA-binding domain)
2it0_B (Iron dependent repressor, N-terminal DNA binding domain, Iron dependent repressor, metal binding and dimerisation domain, Winged helix DNA-binding domain)
2it0_D (Iron dependent repressor, N-terminal DNA binding domain, Iron dependent repressor, metal binding and dimerisation domain, Winged helix DNA-binding domain)
Binding Motifs: 1u8r_ABCD AGCAcAGGCTgCCCTAA
1u8r_B CCcTaA
1u8r_GHIJ TTAGCACAGGCTGCCCT
2isz_ABCD AGnanAGGCTnCCCt
2isz_B TTAGGG
2it0_ABCD AGGGnAGCCTnnGCT
2it0_B TTAGGG
			
Publications: Wisedchaisri G, Holmes R.K, Hol W.G. Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions. Journal of molecular biology 342:1155-69 (2004). [Pubmed]


Wisedchaisri G, Chou C.J, Wu M, Roach C, Rice A.E, Holmes R.K, Beeson C, Hol W.G. Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Biochemistry 46:436-47 (2007). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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