DNA Binding Motif

						

			
Accessions: UP00425A_1 (UniPROBE 20160601), UP00426A_1 (UniPROBE 20160601)

			
Names: AP-1, c-fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, G0S7, Jun_Fos, Proto-oncogene c-Fos, Activator protein 1, AP1, c-Jun, p39, Proto-oncogene c-Jun, Transcription factor AP-1, V-jun avian sarcoma virus 17 oncogene homolog
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 14
Consensus: kkwATGAsKCATmy
Weblogo: 
PSSM: P0      A      C      G      T
01   0.21   0.14   0.40   0.25      k
02   0.19   0.10   0.36   0.35      k
03   0.35   0.13   0.22   0.31      w
04   0.80   0.05   0.13   0.01      A
05   0.01   0.02   0.01   0.96      T
06   0.01   0.01   0.96   0.02      G
07   0.98      0   0.01   0.01      A
08   0.01   0.45   0.54   0.01      s
09   0.02   0.01   0.29   0.69      K
10   0.08   0.90   0.01   0.01      C
11   0.97   0.01   0.01   0.01      A
12   0.02   0.23   0.04   0.70      T
13   0.34   0.40   0.13   0.14      m
14   0.11   0.44   0.14   0.31      y
Type: Heterodimer
Binding TFs: UP00425A (bZIP transcription factor, Basic region leucine zipper)
UP00426A (bZIP transcription factor, bZIP Maf transcription factor, Jun-like transcription factor, Basic region leucine zipper)
Binding Sites: GTGACTCA
TGACGTCA
AAAATTTT
ACGTCATC
ATGACGCA
ATGACGTG
ATGACTAA
ATGACTCA
ATGAGTCA
CTGACTCA
CTGAGTCA
GTGAGTCA
GTGCGTCA
TGCGTCAA
ATGCGTCA
CGATGACG
CGTACAAA
CGTCATTA
GATGACGC
GCAATTGC
			
Publications: Alibés A, Nadra AD, De Masi F, Bulyk ML, Serrano L, Stricher F. Using protein design algorithms to understand the molecular basis of disease caused by protein-DNA interactions: the Pax6 example. Nucleic Acids Res. (2010) Aug 4. [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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