Transcription Factor
| Accessions: | UP00426A (UniPROBE 20160601) |
| Names: | Activator protein 1, AP-1, AP1, c-Jun, Jun, p39, Proto-oncogene c-Jun, Transcription factor AP-1, V-jun avian sarcoma virus 17 oncogene homolog |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q6FHK0 |
| Description: | Transcription factor AP-1: Transcription factor that recognizes and binds to the enhancer heptamer motif 5\'-TGA[CG]TCA-3\' |
| Length: | 103 |
| Pfam Domains: | 1-26 Jun-like transcription factor 33-97 bZIP Maf transcription factor 35-98 bZIP transcription factor 40-95 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 PVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLE 60 61 RIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNS |
| Interface Residues: | 43, 46, 47, 48, 50, 51, 54, 55, 58 |
| 3D-footprint Homologues: | 7x5e_F, 2wt7_A, 1gd2_G, 2wt7_B, 1skn_P, 4eot_A, 2dgc_A, 5t01_B, 1dh3_C, 5vpe_C, 5vpe_D |
| Binding Motifs: | UP00426A_1 kkwATGAsKCATmy |
| Binding Sites: | GTGACTCA TGACGTCA AAAATTTT ACGTCATC ATGACGCA ATGACGTG ATGACTAA ATGACTCA ATGAGTCA CTGACTCA CTGAGTCA GTGAGTCA GTGCGTCA TGCGTCAA ATGCGTCA CGATGACG CGTACAAA CGTCATTA GATGACGC GCAATTGC |
| Publications: | Alibés A, Nadra AD, De Masi F, Bulyk ML, Serrano L, Stricher F. Using protein design algorithms to understand the molecular basis of disease caused by protein-DNA interactions: the Pax6 example. Nucleic Acids Res. (2010) Aug 4. [Pubmed] |
| Related annotations: | PaperBLAST |
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