DNA Binding Motif

						

			
Accessions: 2xro_ABEF (3D-footprint 20231221)

			
Names: HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGV
Organisms: Pseudomonas putida, strain DOT-T1E
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of TtgV in complex with its DNA operator
Length: 35
Consensus: TnTCAnnnnnTGCTAnnnnnTACCGnnnnnCGAnT
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0      0     96      T
02     24     24     24     24      n
03     11      8      7     70      T
04      0     96      0      0      C
05     96      0      0      0      A
06     24     24     24     24      n
07     24     24     24     24      n
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11      0      0      0     96      T
12      0      0     96      0      G
13      3     87      3      3      C
14      7      7      9     73      T
15     96      0      0      0      A
16     24     24     24     24      n
17     24     24     24     24      n
18     24     24     24     24      n
19     24     24     24     24      n
20     24     24     24     24      n
21      0      0      0     96      T
22     73      9      7      7      A
23      3     87      3      3      C
24      0     96      0      0      C
25      0      0     96      0      G
26     24     24     24     24      n
27     24     24     24     24      n
28     24     24     24     24      n
29     24     24     24     24      n
30     24     24     24     24      n
31      0     96      0      0      C
32      0      0     96      0      G
33     84      6      3      3      A
34     24     24     24     24      n
35      3      3      6     84      T
Type: Heterodimer
Binding TFs: 2xro_A / 2xro_E (Bacterial transcriptional regulator, Transcriptional regulator, IclR helix-turn-helix domain, Winged helix-turn-helix DNA-binding)
2xro_B / 2xro_F (Bacterial transcriptional regulator, Transcriptional regulator, IclR helix-turn-helix domain, Winged helix-turn-helix DNA-binding)
Binding Sites: 2xro_X
2xro_Y
			
Publications: Lu D, Fillet S, Meng C, Alguel Y, Kloppsteck P, Bergeron J, Krell T, Gallegos M.T, Ramos J, Zhang X. Crystal structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators. Genes & development 24:2556-65 (2010). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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