Transcription Factor
| Accessions: | Tcf7_DBD (HumanTF 1.0), UP00054A (UniPROBE 20160601) |
| Names: | T-cell factor 1, T-cell-specific transcription factor 1, TCF-1, TCF-7, Tcf7, TCF7_MOUSE, Transcription factor 7, AI465550, T cell factor-1, T-cell specific, Tcf1 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q00417 |
| Description: | Transcription factor 7, T-cell specific |
| Notes: | Ensembl ID: ENSMUSG00000000782; DNA-binding domain sequence; TF family: HMG; Clone source: Hughes lab. |
| Length: | 101 |
| Pfam Domains: | 17-85 HMG (high mobility group) box 18-75 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 KTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSR 60 61 EEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKH |
| Interface Residues: | 19, 22, 24, 25, 28, 32, 43, 44, 45, 48, 86, 88, 90, 93 |
| 3D-footprint Homologues: | 2lef_A, 4y60_C, 1o4x_B, 3f27_D, 6jrp_D, 1qrv_A, 3u2b_C, 7m5w_A, 2gzk_A, 4s2q_D, 1j5n_A, 1hry_A |
| Binding Motifs: | UP00054A_1 twwasWTCAAAGgrahh UP00054A_3 ddkycCTTTGATstwta Tcf7_DBD aAASATCAAAGg UP00054A_2 cyktaTTAbaaayma UP00054A_4 sdrsWTCAATCrstww |
| Binding Sites: | AACATCAA AATCAAAG ACATCAAA ACTTCAAA ACTTTGAT AGATCAAA AGATCAAT ATCAAAGA ATCAAAGC ATCAAAGG CATCAAAG CCTTTGAA CTTCAAAG CTTTGATA CTTTGATC GATCAAAA GCCTTTGA GGATCAAA TCTTTGAA TGATCAAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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