DNA Binding Motif

Accessions: UP00054A_1 (UniPROBE 20160601)
Names: AI465550, T cell factor-1, T-cell factor 1, T-cell specific, T-cell-specific transcription factor 1, Tcf-1, Tcf1, Tcf7, Transcription factor 7
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 17
Consensus: twwasWTCAAAGgrahh
Weblogo:
PSSM: P0 A C G T
01 0.17 0.20 0.22 0.41 t
02 0.34 0.23 0.14 0.29 w
03 0.30 0.17 0.14 0.38 w
04 0.60 0.05 0.13 0.21 a
05 0.04 0.38 0.53 0.05 s
06 0.73 0.01 0.01 0.26 W
07 0.07 0.01 0 0.92 T
08 0.05 0.82 0.10 0.04 C
09 0.96 0.01 0.01 0.03 A
10 0.96 0 0.02 0.02 A
11 0.94 0.01 0.02 0.04 A
12 0.16 0.06 0.76 0.02 G
13 0.23 0.15 0.52 0.09 g
14 0.56 0.12 0.25 0.06 r
15 0.49 0.21 0.12 0.17 a
16 0.31 0.25 0.13 0.31 h
17 0.33 0.25 0.12 0.30 h
Binding TFs: UP00054A (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: AACATCAA
AATCAAAG
ACATCAAA
ACTTCAAA
ACTTTGAT
AGATCAAA
AGATCAAT
ATCAAAGA
ATCAAAGC
ATCAAAGG
CATCAAAG
CCTTTGAA
CTTCAAAG
CTTTGATA
CTTTGATC
GATCAAAA
GCCTTTGA
GGATCAAA
TCTTTGAA
TGATCAAA
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

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