DNA Binding Motif

						

			
Accessions: Tcf7_DBD (HumanTF 1.0), MA0769.1 (JASPAR 2024)

			
Names: Tcf7
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 12
Consensus: aAASATCAAAGg
Weblogo: 
PSSM: P0      A      C      G      T
01    552     68    117     97      a
02    791     31    144    111      A
03    906      4     27     31      A
04      5    277    744      6      S
05    912      2      4     42      A
06      0      5     18    874      T
07     21   1018     28     21      C
08    919      0      5      6      A
09    921      6     10      3      A
10    915      0      0      4      A
11     32      0    846      0      G
12    159    146    600     89      g
Type: Heterodimer
Binding TFs: Q00417 (HMG (high mobility group) box, N-terminal CTNNB1 binding, Domain of unknown function (DUF1898))
Tcf7_DBD (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Q00417
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Fang M, Li J, Blauwkamp T, Bhambhani C, Campbell N, Cadigan KM. C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila. EMBO J 25:2735-45 (2006). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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