Transcription Factor

						

			
Accessions: MEIS2_Full (HumanTF2 1.0)

			
Names: Homeobox protein Meis2, Meis1-related protein 1, MEIS2, MEIS2_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: O14770
Notes: Ensembl ID: ENSG00000134138; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: HomeodomainTALE; Clone source: Jolma et al. 2013
Length: 478
Pfam Domains:   278-333 Homeobox domain
  294-333 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV   60
  61 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN  120
 121 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK  180
 181 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH  240
 241 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT  300
 301 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS  360
 361 PEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLR  420
 421 HGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ*
Interface Residues: 276, 277, 279, 280, 324, 325, 328, 329, 330, 332, 333, 364, 367
3D-footprint Homologues: 4j19_B, 6fqp_B, 1au7_A, 1puf_B, 1le8_A, 7q3o_C, 3rkq_B, 5hod_A, 2d5v_B, 6fqq_E, 1le8_B, 5zfz_A, 3cmy_A, 1fjl_B, 4xrm_B, 1mnm_C, 6a8r_A, 3lnq_A, 1k61_B, 8g87_X, 4xrs_G
Binding Motifs: MEIS2_HOXA13 CTCGTAAAmCTGTCA
MEIS2_ONECUT2_1 kTGACAGcwAATCrATas
MEIS2_ONECUT2_2 wTGACAgawAATCGATAm
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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