DNA Binding Motif

						

			
Accessions: MEIS2_HOXA13 (HumanTF2 1.0)

			
Names: MEIS2_HOXA13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; PWM is from validation experiment performed with full-length TFs and is not included into the dendrograms
Length: 15
Consensus: CTCGTAAAmCTGTCA
Weblogo: 
PSSM: P0      A      C      G      T
01    309   6632    832    108      C
02    128   1604      0   5154      T
03   1946   5564     37    582      C
04   2811      0  12875     19      G
05      0     66      4   6801      T
06   6684    156      0    562      A
07   6788     40     15      0      A
08   6804      0      0      0      A
09   3205   2265    470    848      m
10   1258   4697    543    290      C
11    251   2002     43   6618      T
12    191     94   6797    119      G
13    608   1288    242   6726      T
14    146   6772    248    104      C
15   6695    598    995    518      A
Type: Heterodimer
Binding TFs: HOXA13_TF2 (Homeobox domain, Hox protein A13 N terminal)
HOXA13_Full (Homeobox domain, Hox protein A13 N terminal)
MEIS2_TF1 (Homeobox domain, Homeobox KN domain)
MEIS2_Full (Homeobox domain, Homeobox KN domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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