Transcription Factor

						

			
Accessions: 4r2a_A (3D-footprint 20231221), 4r2c_A (3D-footprint 20231221), 4x9j_A (3D-footprint 20231221)

			
Names: AT225, Early growth response protein 1, EGR-1, EGR1_HUMAN, Nerve growth factor-induced protein A, NGFI-A, Transcription factor ETR103, Transcription factor Zif268, Zinc finger protein 225, Zinc finger protein Krox-24
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P18146
Length: 86
Pfam Domains:      4-28 C2H2-type zinc finger
     4-28 Zinc finger, C2H2 type
    21-44 Zinc-finger double domain
    34-56 Zinc finger, C2H2 type
    34-56 C2H2-type zinc finger
    48-72 Zinc-finger double domain
    62-84 Zinc finger, C2H2 type
    62-80 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEK   60
  61 PFACDICGRKFARSDERKRHTKIHLR
Interface Residues: 16, 17, 18, 19, 20, 22, 23, 44, 45, 46, 47, 48, 50, 51, 52, 72, 73, 74, 75, 76, 77, 78, 79, 80
3D-footprint Homologues: 1tf3_A, 6jnm_A, 7n5w_A, 2kmk_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 1g2f_F, 5k5l_F, 8ssu_A, 1tf6_A, 6ml4_A, 4x9j_A, 2i13_A, 6blw_A, 5kkq_D, 2wbs_A, 1ubd_C, 6u9q_A, 5ei9_F, 2jpa_A, 1mey_C, 5kl3_A, 7ysf_A, 1f2i_J, 6wmi_A, 7eyi_G, 5v3j_F, 8h9h_G, 2lt7_A, 6e94_A, 6a57_A, 8cuc_F, 7y3l_A, 3uk3_C, 5k5i_A, 1llm_D, 5yel_A, 7txc_E, 2drp_D, 4m9v_C, 7y3m_I, 8gn3_A, 5yj3_D
Binding Motifs: 4r2a_A GCGTGGGcg
4r2c_A GCGTGGGGt
4x9j_A annCCCAnnC
Binding Sites: 4r2c_B
4r2a_C / 4r2c_C
4x9j_B
4x9j_C
4r2a_B
			
Publications: Hashimoto H, Olanrewaju Y.O, Zheng Y, Wilson G.G, Zhang X, Cheng X. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes & development 28:2304-13 (2014). [Pubmed]


Zandarashvili L, White MA, Esadze A, Iwahara J. Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1. FEBS Lett 589:1748-53 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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