Transcription Factor

						

			
Accessions: 1t2k_A (3D-footprint 20231221), 2o6g_E (3D-footprint 20231221), 2o6g_G (3D-footprint 20231221)

			
Names: Interferon regulatory factor 3, IRF-3, IRF3_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q14653
Length: 110
Pfam Domains:     5-109 Interferon regulatory factor transcription factor
Sequence: 
(in bold interface residues)		   1 TPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATG   60
  61 AYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNS
Interface Residues: 38, 40, 72, 76, 77, 79, 80, 83, 84
3D-footprint Homologues: 2o61_A, 2pi0_B, 1if1_B, 2irf_L, 7oot_B
Binding Motifs: 1t2k_ABCD TTTAAnTTTnnnnATGTCAA
2o6g_E TTTcCnnaT
2o6g_EFGH GGArAnTGAAAGGGAAAnTnAA
Binding Sites: 2o6g_C
2o6g_D
			
Publications: Panne D, Maniatis T, Harrison S.C. Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. The EMBO journal 23:4384-93 (2004). [Pubmed]


Panne D, Maniatis T, Harrison S.C. An atomic model of the interferon-beta enhanceosome. Cell 129:1111-23 (2007). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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