DNA Binding Motif

						

			
Accessions: 2o6g_EFGH (3D-footprint 20231221)

			
Names: Interferon regulatory factor 3
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of IRF-3 bound to the interferon-b enhancer
Length: 22
Consensus: GGArAnTGAAAGGGAAAnTnAA
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0     96      0      G
02      0      0     96      0      G
03     96      0      0      0      A
04     57      1     38      0      r
05     96      0      0      0      A
06     24     24     24     24      n
07      1      6      5     84      T
08      0      1     92      3      G
09     80      6      5      5      A
10     89      0      7      0      A
11     69      5      1     21      A
12      1      5     84      6      G
13      0      0     96      0      G
14      0      2     94      0      G
15     96      0      0      0      A
16     96      0      0      0      A
17     88      4      3      1      A
18     24     24     24     24      n
19      9      8      7     72      T
20     24     24     24     24      n
21     86      4      3      3      A
22     88      1      3      4      A
Type: Heterodimer
Binding TFs: 2o6g_E / 2o6g_G (Interferon regulatory factor transcription factor)
2o6g_F / 2o6g_H (Interferon regulatory factor transcription factor)
Binding Sites: 2o6g_C
2o6g_D
			
Publications: Panne D, Maniatis T, Harrison S.C. An atomic model of the interferon-beta enhanceosome. Cell 129:1111-23 (2007). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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