DNA Binding Motif

						

			
Accessions: 1t2k_ABCD (3D-footprint 20231221)

			
Names: Interferon regulatory factor 3
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA
Length: 20
Consensus: TTTAAnTTTnnnnATGTCAA
Weblogo: 
PSSM: P0      A      C      G      T
01     10      4      9     73      T
02      0      0      0     96      T
03     12      9      7     68      T
04     78     14      2      2      A
05     66      9     12      9      A
06     24     24     24     24      n
07      7      2      2     85      T
08      0      0      0     96      T
09      7      7      2     80      T
10     24     24     24     24      n
11     24     24     24     24      n
12     24     24     24     24      n
13     24     24     24     24      n
14     71      9      9      7      A
15      0      0      0     96      T
16      0      0     96      0      G
17      0      0      0     96      T
18      0     96      0      0      C
19     96      0      0      0      A
20     93      1      0      2      A
Type: Heterodimer
Binding TFs: 1t2k_A (Interferon regulatory factor transcription factor)
1t2k_B (Interferon regulatory factor transcription factor)
1t2k_C (bZIP transcription factor, Basic region leucine zipper)
1t2k_D (bZIP transcription factor, Basic region leucine zipper)
Binding Sites: 1t2k_E
1t2k_F
			
Publications: Panne D, Maniatis T, Harrison S.C. Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. The EMBO journal 23:4384-93 (2004). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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