Transcription Factor

Accessions: UP00048A (UniPROBE 20160601)
Names: alpha, Nr1b1, RAR alpha 1, RAR-alpha, Rara, RARalpha1, retinoic acid receptor, Retinoic acid receptor alpha
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P11416
Description: retinoic acid receptor, alpha
Length: 107
Pfam Domains: 18-86 Zinc finger, C4 type (two domains)
Sequence:
(in bold interface residues)
1 EIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKN 60
61 CIINKVTRNRCQYCRLQKCFDVGMSKESVRNDRNKKKKEAPKPECSE
Interface Residues: 27, 28, 30, 31, 37, 38, 39, 40, 41, 43, 44, 45, 48, 50, 54, 69, 73, 75, 77, 91, 93, 95, 98
3D-footprint Homologues: 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 7xv6_B, 4iqr_B, 2han_A, 1hcq_E, 8cef_H, 2han_B, 1kb2_B, 2a66_A, 8hbm_B, 5krb_G, 2nll_B, 1lat_A, 4yhx_A, 4hn5_B, 5e69_A, 3g6t_A, 1r4i_A, 5emc_A, 7prw_B, 5cbx_B, 4tnt_B, 5cbz_E
Binding Motifs: UP00048A_1 kmycAAAGGTCAcstg
UP00048A_2 akagysGGGTCAakkm
Binding Sites: AAGGTCAA
AAGGTCAC
AAGGTCAT
AATGACCT
AGAGGTCA
AGGGGTCA
AGGTCAAA
AGGTCAAG
AGGTCACA
AGGTCACC
AGGTCACG
AGGTCAGC
AGGTCATC
CAAGGTCA
CGAGGTCA
GAAGGTCA
GAGGTCAA
GAGGTCAC
TAAGGTCA
CTGACCTC
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.