Transcription Factor

						

			
Accessions: Tcfap2a_DBD (HumanTF 1.0), UP00005A (UniPROBE 20160601)

			
Names: Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2 transcription factor, AP2-alpha, AP2A_MOUSE, Tcfap2a, Transcription factor AP-2-alpha, Activating enhancer-binding protein 2 alpha, alpha, Ap-2 (a), AP-2 alpha, Ap2tf, Tfap2a, transcription factor AP-2, Transcription factor AP-2 alpha
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, UniPROBE 20160601 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P34056
Description: transcription factor AP-2, alpha: Mus musculus transcription factor AP-2, alpha, mRNA
Notes: Ensembl ID: ENSMUSG00000021359; DNA-binding domain sequence; TF family: AP2; Clone source: Hughes lab.
Length: 238
Pfam Domains:    16-222 Transcription factor AP-2
Sequence: 
(in bold interface residues)		   1 AIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGG   60
  61 VLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETE  120
 121 FPAKAVAEFLNRQHSDPNEQVARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPG  180
 181 IQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSS
Interface Residues: 31, 65, 66
3D-footprint Homologues: 8j0k_B
Binding Motifs: UP00005A_1 wwtsCCysrGGsraa
Tcfap2a_DBD_1 yGCCCyvrGGCa
Tcfap2a_DBD_2 mGCCysAGGCd
Tcfap2a_DBD_3 tGCCCysrGGGCa
UP00005A_2 tmrCCybwGGkCak
Binding Sites: CCCCAGGC
CCCCAGGG
CCCCCAGG
CCCCCGGG
CCCCGAGG
CCCCGGGC
CCCCGGGG
CCCGAGGG
CCCGCGGG
CCCGGGGC
CCCTCAGG
CCCTGAGG
CCGCAGGC
CCGGAGGC
CCGGGGGC
CCTCAGGC
CCTCCGGC
CCTCGGGC
CCTGAGGC
CCTGGGGC
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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