Transcription Factor
| Accessions: | Irx3_DBD (HumanTF 1.0), UP00223A (UniPROBE 20160601) |
| Names: | Homeodomain protein IRXB1, Iroquois homeobox protein 3, Iroquois-class homeodomain protein IRX-3, Irx3, IRX3_MOUSE, Iroquois related homeobox 3 (Drosophila) |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P81067 |
| Description: | Iroquois related homeobox 3 (Drosophila) |
| Notes: | Ensembl ID: ENSMUSG00000031734; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 124 |
| Pfam Domains: | 30-75 Homeobox domain 33-72 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 PHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLT 60 61 QVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEESKRELEMEEEG 120 121 NAYG |
| Interface Residues: | 18, 20, 21, 23, 60, 61, 63, 64, 67, 68, 69, 71, 72, 74, 75 |
| 3D-footprint Homologues: | 1mnm_C, 3d1n_M, 2ld5_A, 5jlw_D, 1ig7_A, 2hdd_A, 1le8_B, 7psx_B, 4xrs_G, 2r5y_A, 1puf_B, 1fjl_B, 5zjt_E, 3rkq_B, 5flv_I, 3a01_E, 2d5v_B, 6fqp_B, 4cyc_A, 1nk2_P, 1b72_A, 3cmy_A, 2h1k_B, 1k61_B, 6fqq_E, 4xrm_B, 2lkx_A, 1puf_A, 1du0_A, 5zfz_A, 2hos_A |
| Binding Motifs: | UP00223A_1 wrwrTACATGTAawwyw Irx3_DBD ywACATGAmAww UP00223A_2 wwdaTACATGTAawwyw |
| Binding Sites: | AAAACATG AAACATGT AACATGAT AACATGTA AACATGTT ACAACATG ACATGTAA ACATGTAC ACATGTAG ACATGTAT ACATGTCA AGTACAAG ATGTACAA ATGTACAT ATTACATG CATGTAAA CATGTACA CATGTTAA CTTGTACA GTACAAGA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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