Transcription Factor
| Accessions: | UP00502A (UniPROBE 20160601), UP00502B (UniPROBE 20160601) |
| Names: | S. purpuratus Tbrain (T-box transcription factor), SpTbr_rep1, SpTbr_rep2 |
| Organisms: | Strongylocentrotus purpuratus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | S. purpuratus Tbrain (T-box transcription factor) |
| Length: | 193 |
| Pfam Domains: | 9-186 T-box |
| Sequence: (in bold interface residues) | 1 ANGPGKASVYLCNRDLWRKFHQHKTEMIITKQGRRMFPQLVFKLTGLNPTSQYNVFVDMV 60 61 LCDPNQWKFQCGKWIPCGQAENIPKVSNIYLHPDSPSNGLHWMHQDIVFSKLKLTNHRAK 120 121 DNGFVILNSMHQYQPRIHVLELSESRSIQTHSFPETQFFGVTAYQNTDVTQLKIDYNPFA 180 181 KGFRDNYDNLSPR |
| Interface Residues: | 34, 47, 162, 163, 179, 182, 183 |
| 3D-footprint Homologues: | 6f59_B, 4a04_B, 1h6f_B, 5flv_I, 1xbr_B, 2x6v_A, 5o63_B |
| Binding Motifs: | UP00502A_1 ycgswvdAGGTGTGAAydrkwch UP00502B_1 smkvssgAGGTGyGAAmyrsdy |
| Binding Sites: | AAGTGTGA AGGTGAGA AGGTGCGA AGGTGTCA AGGTGTCG AGGTGTGA AGGTGTTA AGTGTGAA ATCACACC ATGTGTGA CTTCACAC GGGTGTGA GGTGCGAA GGTGTGAA GTGTGAAA GTGTGAAC TCACACCA AAGGTGTC AAGTGCGA ACACCTCC AGGTGCTA AGGTGTGG AGGTGTTG CACACCTC CTCACACC GATCACAC TGTGTGAA |
| Publications: | Cheatle Jarvela AM, Brubaker L, Vedenko A, Gupta A, Armitage BA, Bulyk ML, Hinman VF. Modular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networks. Mol Biol Evol 31:2672-88 (2014). [Pubmed] |
| Related annotations: | PaperBLAST |
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