Transcription Factor

Accessions: UP00303A (UniPROBE 20160601)
Names: Fhl1, P8283.15, Pre-rRNA-processing protein FHL1, YPR104C
Organisms: Saccharomyces cerevisiae
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P39521
Description: Putative transcriptional regulator with similarity to DNA-binding domain of Drosophila forkhead; required for rRNA processing
Length: 207
Pfam Domains: 51-139 Fork head domain
Sequence:
(in bold interface residues)
1 KNEPKSKKKITTGAKPKKAQTKPAVKKEKKPPKIPKKVYTLEEIPVEYRTKPTVSYSAML 60
61 TTCIRKYSTAKGMSLSEIYAGIRELFPYYKYCPDGWQSSVRHNLSLNKSFRKVSKEGKGW 120
121 LWGLDEEYIAERERQKKKQSEIAVAKAQAAQLKLEQQQHKLQQVPQRGKKDIVSQRSNVN 180
181 ARKQNISQTLAANRAASNRKNTASDNQ
Interface Residues: 95, 97, 98, 99, 101, 102, 103, 105, 106, 115, 118
3D-footprint Homologues: 7vox_H, 2hdc_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 3l2c_A, 3qrf_G
Binding Motifs: UP00303A_1 rrwawtGACGCAawtwhgwk
Binding Sites: TGACGCAA
ACGCAAAC
ACGCAAAT
ACGCAATA
AGACGCAA
AGTGCGTC
ATTGCGTC
CGACGCAA
CGTGCGTC
GACGCAAA
GACGCAAC
GACGCACA
GACGCATA
GCGACGCA
GTGACGCA
GTGCGTCA
TGCGTCAA
ACACGCAA
CGACGCAC
GGGACGCA
Publications: *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed]
Related annotations: PaperBLAST

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