Transcription Factor

						

			
Accessions: Spic_DBD (HumanTF 1.0), UP00419A (UniPROBE 20160601)

			
Names: Prf, Pu.1-related factor, Spic, SPIC_MOUSE, Transcription factor Spi-C, AU019198, C76795, Spi-C transcription factor (Spi-1/PU.1 related)
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, UniPROBE 20160601 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q3U0G6
Description: 	Spi-C transcription factor (Spi-1/PU.1 related): transcription factor Spi-C
Notes: Ensembl ID: ENSMUSG00000004359; DNA-binding domain sequence; TF family: ETS; Clone source: Hughes lab.
Length: 119
Pfam Domains:    17-101 Ets-domain
Sequence: 
(in bold interface residues)		   1 VQPPFFQQKGGRGRRKLRLFEYLFESLCNSEMVSCIQWVDKARGIFQFISKNKETLAELW   60
  61 GQRKGNRKPMTYQKMARALRNYARTGEIIKIRRKLTYQFSEAVLQRLAPANYLGKDLFY
Interface Residues: 73, 74, 76, 77, 78, 80, 81, 94
3D-footprint Homologues: 1dux_F, 8ee9_F, 3zp5_A, 4mhg_A, 2stt_A, 7jsa_J, 3jtg_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C
Binding Motifs: UP00419A_1 rAAaGmGGAAGTwd
Spic_DBD aAAAAGmGGAAGTa
Binding Sites: AACTTCCC
AACTTCCG
AACTTCCT
AAGAGGAA
ACTTCCCC
ACTTCCCT
ACTTCCGC
ACTTCCGG
ACTTCCTA
ACTTCCTC
ACTTCCTG
AGCGGAAG
AGGAAGTA
AGGAAGTG
CACTTCCG
CGGAAGTA
CTTCCGCA
GGAAGTAA
GGGAAGTA
TTCCGGAA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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