Transcription Factor

						

			
Accessions: 1le9_A (3D-footprint 20231221), 1le9_E (3D-footprint 20231221), 1lei_A (3D-footprint 20231221), 1vkx_A (3D-footprint 20231221), 3gut_A (3D-footprint 20231221), 3gut_C (3D-footprint 20231221), 3gut_E (3D-footprint 20231221), 3gut_G (3D-footprint 20231221)

			
Names: NUCLEAR FACTOR NF-KAPPA-B P65 SUBUNIT, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, TF65_MOUSE, Transcription factor p65, NF-KAPPA B P65 SUBUNIT, TF65_HUMAN
Organisms: Mus musculus, Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q04207
Length: 273
Pfam Domains:     3-168 Rel homology domain (RHD)
Sequence: 
(in bold interface residues)		   1 AYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVT   60
  61 KDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNN  120
 121 NPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICR  180
 181 VNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYA  240
 241 DPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPD
Interface Residues: 15, 17, 18, 20, 21, 23, 24, 25, 117, 169, 171, 200, 228
3D-footprint Homologues: 1nfk_A, 1a66_A, 2o61_A, 1gji_A, 2ram_A, 1imh_C, 7cli_B, 1a3q_A
Binding Motifs: 1le9_AB aGGAaaGTCC
1le9_EF GGAAGTC
1lei_AB TGGGnnngTACA
1vkx_AB GGAanGTCCCa
3gut_ABD GTCCCnnnnGGAAnGTCC
3gut_CF GTCCAnTGGAA
3gut_E TTCC
3gut_EGH TTCCgnnnGGGACnTTCCa
Binding Sites: 3gut_I
3gut_J / 3gut_Y
			
Publications: Berkowitz B, Huang D.B, Chen-Park F.E, Sigler P.B, Ghosh G. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. The Journal of biological chemistry 277:24694-700 (2002). [Pubmed]


Chen-Park F.E, Huang D.B, Noro B, Thanos D, Ghosh G. The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. The Journal of biological chemistry 277:24701-8 (2002). [Pubmed]


Chen F.E, Huang D.B, Chen Y.Q, Ghosh G. Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature 391:410-3 (1998). [Pubmed]


Stroud J.C, Oltman A, Han A, Bates D.L, Chen L. Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR. Journal of molecular biology 393:98-112 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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