DNA Binding Motif

						

			
Accessions: 3gut_EGH (3D-footprint 20231221)

			
Names: Transcription factor p65
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR
Length: 19
Consensus: TTCCgnnnGGGACnTTCCa
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0      0     96      T
02      0      0      0     96      T
03      0     96      0      0      C
04      0     96      0      0      C
05     13     13     57     13      g
06     24     24     24     24      n
07     24     24     24     24      n
08     24     24     24     24      n
09      0      0     96      0      G
10      0      0     96      0      G
11      0      0     96      0      G
12     96      0      0      0      A
13      0     96      0      0      C
14     24     24     24     24      n
15      0      0      0     96      T
16      0      0      0     96      T
17      0     96      0      0      C
18      0     96      0      0      C
19     54     13     13     16      a
Type: Heterodimer
Binding TFs: 3gut_E / 3gut_G (Rel homology domain (RHD))
3gut_H (Rel homology domain (RHD))
Binding Sites: 3gut_I
3gut_J / 3gut_Y
			
Publications: Stroud J.C, Oltman A, Han A, Bates D.L, Chen L. Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR. Journal of molecular biology 393:98-112 (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.