Transcription Factor
| Accessions: | UP00600A (UniPROBE 20160601) |
| Names: | FKLF, FKLF1, KLF11_REF, Krueppel-like factor 11, MODY7, TGFB-inducible early growth response protein 2, TIEG-2, TIEG2, Tieg3, Transforming growth factor-beta-inducible early growth response protein 2 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Krueppel-like factor 11: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. |
| Length: | 112 |
| Pfam Domains: | 15-39 C2H2-type zinc finger 15-39 Zinc finger, C2H2 type 31-57 Zinc-finger double domain 45-69 C2H2-type zinc finger 45-69 Zinc finger, C2H2 type 62-84 Zinc-finger double domain 75-97 C2H2-type zinc finger 75-97 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 QNCVPQVDFSRRRNYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSD 60 61 ELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGK |
| Interface Residues: | 24, 26, 27, 28, 29, 30, 31, 33, 34, 36, 37, 40, 57, 58, 59, 60, 61, 63, 64, 65, 85, 86, 87, 88, 89, 90, 91, 92, 93, 96 |
| 3D-footprint Homologues: | 5k5i_A, 6jnm_A, 3uk3_C, 1tf3_A, 6ml4_A, 7n5w_A, 4x9j_A, 2i13_A, 1llm_D, 5kl3_A, 1ubd_C, 7ysf_A, 5ei9_F, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2kmk_A, 8ssu_A, 2gli_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 8h9h_G, 7eyi_G, 6e94_A, 6wmi_A, 2lt7_A, 6a57_A, 2jpa_A, 8cuc_F, 7y3l_A, 5yel_A, 7txc_E, 2wbs_A, 2drp_D, 1f2i_J, 4m9v_C, 7y3m_I, 8gn3_A, 5yj3_D, 5v3j_F |
| Binding Motifs: | UP00600A_1 ythdwmmmCGCCCCCybskyam |
| Binding Sites: | CCGCCCCC CCCGCCCC ACCGCCCC ACGCCCAC ACGCCCCC ACGCCCCT AGGGGGCG CACGCCCA CACGCCCC CCACCCCC CCCACCCC CCCCGCCC CCCGCCCA CCGCCCAC CGCCCACC CGCCCCCA CGCCCCCC CGCCCCCG GGGGCGTA GGGGCGGA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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