DNA Binding Motif

						

			
Accessions: ETV2_SREBF2_2 (HumanTF2 1.0), UN0521.1 (JASPAR 2024)

			
Names: ETV2_SREBF2, ETV2::SREBF2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: vTsrSGTGACGGAAry
Weblogo: 
PSSM: P0      A      C      G      T
01    202    158    161      9      v
02     79     37     19    363      T
03     53    310    334      7      s
04    250      6    113     22      r
05      5    363    141     13      S
06     24      6    363      1      G
07     13     46      9    363      T
08      3      0    363      0      G
09    363     15     32     16      A
10      0    363      0     25      C
11      7      1    363      2      G
12      3      1    363     33      G
13    363      0     19     17      A
14    332     45     18     31      A
15    198     71    363     35      r
16     30    116     45    172      y
Type: Heterodimer
Binding TFs: SREBF2_TF2 (Helix-loop-helix DNA-binding domain)
ETV2_TF1 (Ets-domain)
SREBF2_TF1 (Helix-loop-helix DNA-binding domain)
Q3KNT2 (Ets-domain)
Q3KNT2
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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