Transcription Factor
| Accessions: | SREBF2_DBD (HumanTF 1.0), SREBF2_TF2 (HumanTF2 1.0) |
| Names: | Q05BD5_HUMAN, SREBF2, Antigen NY-CO-13, Cellular tumor antigen p53, P53_HUMAN, Phosphoprotein p53, Tumor suppressor p53 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q05BD5 |
| Notes: | Ensembl ID: ENSG00000198911; DNA-binding domain sequence; TF family: bHLH; Clone source: MGC, Ensembl ID: ENSG00000198911; Construct type: TF2(3xFLAG); TF family: bHLH; Clone source: Jolma et al. 2013 |
| Length: | 118 |
| Pfam Domains: | 26-76 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMH 60 61 KSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLKIED |
| Interface Residues: | 27, 29, 30, 31, 33, 34, 37, 38, 59, 61 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 1an4_A, 5nj8_D, 7f2f_B, 5eyo_A, 8osl_O, 5v0l_A, 7ssa_L, 5gnj_I, 6g1l_A, 4h10_B, 7xi3_A, 5i50_B, 1am9_A, 7d8t_A, 4zpk_A |
| Binding Motifs: | SREBF2_DBD ATCACGTGAy ELK1_SREBF2_1 rcCGGAAGTsrCGTGA ELK1_SREBF2_2 rtCrCGTGACCGGAAGy ERF_SREBF2_1 rTCACGTGACmGGAAgkr ERF_SREBF2_2 ssCGGAArTCACGTGAy ETV2_SREBF2_1 rTCACGysACCGGAwr ETV2_SREBF2_2 vTsrSGTGACGGAAry RFX3_SREBF2 mTrGyAACrTCACGTGAy |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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