Transcription Factor
| Accessions: | SREBF2_TF1 (HumanTF2 1.0), SREBF2 (HT-SELEX2 May2017) |
| Names: | Antigen NY-CO-13, Cellular tumor antigen p53, P53_HUMAN, Phosphoprotein p53, SREBF2, Tumor suppressor p53, ENSG00000198911 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P04637 |
| Notes: | Ensembl ID: ENSG00000198911; Construct type: TF1(SBP); TF family: bHLH; Clone source: Jolma et al. 2013, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 119 |
| Pfam Domains: | 26-76 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMH 60 61 KSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLKIEDF |
| Interface Residues: | 27, 29, 30, 31, 33, 34, 37, 38, 59, 61 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 1an4_A, 7ssa_L, 5gnj_I, 6g1l_A, 4h10_B, 7xi3_A, 5i50_B, 1am9_A, 7d8t_A, 4zpk_A, 5nj8_D, 7f2f_B, 5eyo_A, 8osl_O, 5v0l_A |
| Binding Motifs: | ELK1_SREBF2_1 rcCGGAAGTsrCGTGA ELK1_SREBF2_2 rtCrCGTGACCGGAAGy ERF_SREBF2_1 rTCACGTGACmGGAAgkr ERF_SREBF2_2 ssCGGAArTCACGTGAy ETV2_SREBF2_1 rTCACGysACCGGAwr ETV2_SREBF2_2 vTsrSGTGACGGAAry RFX3_SREBF2 mTrGyAACrTCACGTGAy SREBF2_3 ATCACGTGAy SREBF2_4 aTCACGCCAy SREBF2_methyl_1 ATCAgGTGAT SREBF2_methyl_2 ATCACmCCAy |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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