DNA Binding Motif

						

			
Accessions: 5c8e_BC (3D-footprint 20231221)

			
Names: Light-dependent transcriptional regulator CarH
Organisms: strain HB27 / ATCC BAA-163 / DSM 7039, Thermus thermophilus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of Thermus thermophilus CarH bound to adenosylcobalamin and a 26-bp DNA segment
Length: 15
Consensus: TACAnnnnnnTGACA
Weblogo: 
PSSM: P0      A      C      G      T
01      6      6      6     78      T
02     96      0      0      0      A
03      0     96      0      0      C
04     78      6      6      6      A
05     24     24     24     24      n
06     24     24     24     24      n
07     24     24     24     24      n
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11     12      6     12     66      T
12      0      0     96      0      G
13     96      0      0      0      A
14      0     72     12     12      C
15     84      0      6      6      A
Type: Heterodimer
Binding TFs: 5c8e_B (MerR family regulatory protein, B12 binding domain, MerR HTH family regulatory protein)
5c8e_C (MerR family regulatory protein, B12 binding domain, MerR HTH family regulatory protein)
Binding Sites: 5c8e_I
5c8e_J
			
Publications: Jost M, Fernández-Zapata J, Polanco MC, Ortiz-Guerrero JM, Chen PY, Kang G, Padmanabhan S, Elías-Arnanz M, Drennan CL. Structural basis for gene regulation by a B12-dependent photoreceptor. Nature 526:536-41 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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