Transcription Factor

Accessions: 5c8e_B (3D-footprint 20231221)
Names: Light-dependent transcriptional regulator CarH, Q746J7_THET2
Organisms: strain HB27 / ATCC BAA-163 / DSM 7039, Thermus thermophilus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q746J7
Length: 276
Pfam Domains: 3-71 MerR HTH family regulatory protein
4-41 MerR family regulatory protein
80-152 B12 binding domain
Sequence:
(in bold interface residues)
1 GVYTIAEVEAMTGLSAEVLRQWERRYGFPKPRRTPGGHRLYSAEDVEALKTIKRWLEEGA 60
61 TPKAAIRRYLAQEVRPEDLGTGLLEALLRGDLAGAEALFRRGLRFWGPEGVLEHLLLPVL 120
121 REVGEAWHRGEIGVAEEHLASTFLRARLQELLDLAGFPPGPPVLVTTPPGERHEIGAMLA 180
181 AYHLRRKGVPALYLGPDTPLPDLRALARRLGAGAVVLSAVLSEPLRALPDGALKDLAPRV 240
241 FLGGQGAGPEEARRLGAEYMEDLKGLAEALWLPRGP
Interface Residues: 17, 20, 21, 24, 25, 38
3D-footprint Homologues: 7tec_A, 5c8e_C, 6ldi_G, 1r8d_B, 5d8c_A, 6xh7_H, 4r24_B, 5i44_I, 7tea_B, 4r4e_B, 6jgx_B
Binding Motifs: 5c8e_BC TACAnnnnnnTGACA
Publications: Jost M, Fernández-Zapata J, Polanco MC, Ortiz-Guerrero JM, Chen PY, Kang G, Padmanabhan S, Elías-Arnanz M, Drennan CL. Structural basis for gene regulation by a B12-dependent photoreceptor. Nature 526:536-41 (2015). [Pubmed]
Related annotations: PaperBLAST

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