DNA Binding Motif

						

			
Accessions: 6vvs_FT (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor SigA
Organisms: Mycobacterium smegmatis, Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with antibiotic Sorangicin
Length: 25
Consensus: AGCAnAnnnnnnnncnnnTGTCaAG
Weblogo: 
PSSM: P0      A      C      G      T
01     96      0      0      0      A
02      0      0     96      0      G
03      0     96      0      0      C
04     96      0      0      0      A
05     24     24     24     24      n
06     78      6      6      6      A
07     24     24     24     24      n
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11     24     24     24     24      n
12     24     24     24     24      n
13     24     24     24     24      n
14     24     24     24     24      n
15     12     60     12     12      c
16     24     24     24     24      n
17     24     24     24     24      n
18     24     24     24     24      n
19     12      6      6     72      T
20      0      0     96      0      G
21      0      0      0     96      T
22      0     96      0      0      C
23     60     12     12     12      a
24     96      0      0      0      A
25      0      0     96      0      G
Binding TFs: 6vvs_F (Sigma-70 factor, region 1.2, Sigma-70 region 3, Sigma-70 region 2 , Sigma-70, region 4)
Binding Sites: 6vvs_O
6vvs_P
			
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.