Transcription Factor

						

			
Accessions: 6vvs_F (3D-footprint 20231221)

			
Names: A0QW02_MYCS2, RNA polymerase sigma factor SigA
Organisms: Mycobacterium smegmatis, Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: A0QW02
Length: 305
Pfam Domains:      2-36 Sigma-70 factor, region 1.2
   72-142 Sigma-70 region 2 
  151-227 Sigma-70 region 3
  240-293 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 SADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKLPVQQRRDMQW   60
  61 ICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKF  120
 121 STYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEM  180
 181 DITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSV  240
 241 LETLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVL  300
 301 RDYLD
Interface Residues: 266, 267, 276, 277, 278, 279, 281, 282
3D-footprint Homologues: 3n97_A, 6ido_B, 8cyf_B
Binding Motifs: 6vvs_F CTTGACAnnnnnnnnnnnnTnTGCT
6vvs_FT AGCAnAnnnnnnnncnnnTGTCaAG
Binding Sites: 6vvs_O
6vvs_P
			
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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