DNA Binding Motif

						

			
Accessions: ETV5_DRGX_1 (HumanTF2 1.0), MA1944.1 (JASPAR 2024)

			
Names: ETV5_DRGX, ETV5::DRGX
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: rsmGGAAGyAATTA
Weblogo: 
PSSM: P0      A      C      G      T
01    239     50    201     46      r
02     95    249    191     36      s
03    157    283     12     16      m
04      4      3    440      2      G
05      0     11    440      0      G
06    440     10      0      1      A
07    329     29     15    111      A
08     51     51    440      0      G
09     31    178     35    262      y
10    440     18    141      3      A
11    440     51     79     56      A
12     16     13     29    440      T
13     37     79     32    440      T
14    440     20     88     37      A
Type: Heterodimer
Binding TFs: P41161 (Ets-domain, PEA3 subfamily ETS-domain transcription factor N terminal domain)
DRGX_TF2 (Homeobox domain)
ETV5_TF1 (Ets-domain)
P41161
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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